Driving with poor eyesight, reaction time or mental clarity obviously creates many dangers, leading many senior citizens to give up their car keys.

But a new analysis of previous research on the topic shows a higher risk of social and mental challenges for seniors after they stop driving.

To get a big-picture view of the matter, researchers at Columbia University Medical Center reviewed 16 studies on the topic involving people over age 55 in the United States and three other countries. The review, which compared former drivers with older drivers still on the road, was published in the Journal of the American Geriatrics Society.

Evaluation of the studies showed a strong trend toward significantly greater depression symptoms among people who had stopped driving. Not surprisingly, researchers also noted significantly less social engagement and satisfaction among the non-driving seniors. Other outcomes the 16 studies assessed included general health problems, an increased risk of death in the three years after driving ended, a greater likelihood of moving into a long-term care facility and reduced mental ability.

While there are no definitive data on the issue, researchers note some evidence that having alternative transportation for seniors who stop driving might not ward off depression.

But the clear tie to social deficiencies and increased depression deserves attention. Finding ways to help seniors keep driving safely — such as ensuring regular vision care — may be appropriate in some cases. For those who do need to give up the keys, friends and family members should keep a watchful eye out for health problems that may arise.